Cancer Immunotherapy Use on Cancer Patients

Recent advances in treating cancer patients have resulted in the development of biological therapies that can prove to be a promising alternative to conventional cancer therapies. Immunotherapy harnesses the body’s immune system to identify and fight effectively against cancer cells.

Immunotherapy works by attacking the growth of cancer cells or stimulating the immune system to kill cancer cells. Contradictory to the standard cancer treatment regimes such as chemotherapy, radiation therapy, which act on both normal and cancerous cells, immuno-therapeutic treatments are highly specific. A wide range of cancer immuno-therapy approaches exists such as immune checkpoint blockers, cancer vaccines, immune-modulators, monoclonal antibodies and cell based immuno-therapies have demonstrated to be effective against cancer patients.

The most commonly targeted form of cancer chemotherapy is the use of monoclonal antibodies as they can be tailor-made in the laboratory. They have unique antigen specificity thereby allowing themselves to attach to specific epitopes on cancer cells. This flags the cancer cells and makes it more visible to the immune system so that it can find and destroy those cells. Currently, most of the monoclonal antibodies are undergoing phase 3 clinical trials or awaiting FDA review process. Unlike monoclonal antibodies, non-specific immuno-therapy approaches such as administration of immuno-modulatory cytokines are also being used to treat melanoma. Cytokines are hormones that are endogenously produced by the body to enhance or suppress T-cell response against cancer cells. IFN-α and IL-2 are most commonly characterized cytokines used in cancer immuno-therapy.

The primary cell-based immuno-therapy strategy which is successful these days is the use of T-cell therapy, wherein cancer T cells removed from blood are modified with chimeric antigen receptor (CAR) and is then infused back into the patients to treat metastatic cancer. Another form of cell-based immuno-therapy used is tumor-infiltrating lymphocytes (TIL) therapy, wherein TIL is surgically removed from tumor tissue and is considerably increased in the laboratory by adding cytokines to it and is then re-infused back into the patient.

A promising treatment that has emerged in recent times for treatment of melanoma is the use of immune checkpoint inhibitors. They act by inhibiting the checkpoint receptors on T cells that act as brakes to the immune system thereby mediating anti-tumor responses. Some of the commonly used antibody inhibitors that have been commercialized are PD-1, PDL-1, and CTLA-4. Another more focused approach to cancer immuno-therapy is the use of vaccines to encourage the immune system to generate antibodies that can target tumor specific antigens, thereby eradicating cancerous cells. Cancer vaccines include peptide-based, dendritic cell-based, tumor cell-based and DNA cell based. Cancer vaccines can be broadly classified as preventive or therapeutic. Preventive vaccines are commercially available for against cervical and liver cancer causing viruses such as human Papillomavirus and Hepatitis B virus, respectively.

However, in spite of these advances, limitation such as tumor heterogeneity, unpredictable efficacy and identification of potential markers still exist in the field of cancer immuno-therapy. Therefore, new more targeted cancer immuno-therapies and preventive strategies are being developed and tested, which will deliver novel efficacious therapy against relapsed or refractory cancer patients.

Importance of Right Glassware

Eating and drinking may be just another imperative thing to do for humans for their survival, but they are impacted by a lot of things. One of the factors that has a direct effect on the manner in which the food is targeted and absorbed by the body is the psychology with which one consumes their food and drinks and this psychology is majorly affected by the cutlery and the utensils in which we do this repetitive task. Eating proper is not just about eating the right food in the right manner, but it is also about eating it in the right kind of dishes. The plates and glass in front of us can either make or kill the mood to eat food (no matter how good it is or how well it has been cooked). For example, a normal steel plate can be an immediate mood killer as compared to one made out of some great quality glass. Same goes for the glasses; be it for drinking water, serving alcohol to guests, or just gulping down some wine or beer when you are in the mood.

The entire paragraph can be paraphrased to basically say that the crockery, cutlery, and glasses used for food intake should be swanky and attractive to not only make the food look more good and presentable, but also to add a touch of chic and décor to your kitchen and also leave a good impression on the guests (if and when they come).

BUYING THE RIGHT TYPE OF GLASS DISHES

So far we saw how the type of dishes used can be a buzzkill for many which is why in all sorts of setups (be it your home or a professional environment such as a restaurant or a bar, etc.), following are some factors that one may consider in order to ensure that your crockery and glass dishes always appear at their best:

If plates are the concerned department, it is best advised to stay simple yet elegant and the best way to do so is to go with plain white plates reason being that they are conveniently inexpensive, present the food in the best manner possible, and also do not fade away easily.

For wine glasses, it always suggested to go with those that have a relatively sturdy build to them for them slipping away from your or your guests’ hands are always a great flight risk not worth taking.

For red wine, go with glasses with a wide bowl
For white wine, go with a glass that has a comparatively narrow bowl

Chemistry teaches us that “symmetry leads to stability” and the same should be applied to your crockery. The balance between normal and ornate design plates should be perfect.

For champagne and martini and other types of alcohol glasses, there is no fixed trend you can follow. There are quite a bunch of options to choose from depending upon the alcohol and your taste and preference when it comes to your glassware. For example, the champagne flute is the most common champagne glass, the brandy balloon is the most common glass used to serve brandy, etc.

Get More Reliable Cost Air Ambulance Service In Patna With Medical Team By Global

The demand for hiring an emergency air moving service in Patna is increasing day by day because many people are familiar with the world, in Patna, more reliable and affordable cost of the air Ambulate as well as all other small and big cities Very seriously offer to move ill patients from one end to the other end at a very quick time. We provide commercial and charter air Rehabilitation service in Patna with all types of basic and advanced medical facilities as per the patient’s demand which is very cheap for all the class families. We provide Emergency Air Ambulance 24 hours a day with a long and experienced trained and well-trained MD doctors and special paramedical technicians for proper care and health care at transportation times.

The company has managed to make its Professional services unique in the highly competitive domestic and international market by distributing the highest level commitment. The company started air medieval services from Patna to Delhi from Bangalore to Mumbai and in a short time managed to expand its operations around the world.

This Company offers emergency air ambulance services, ranging from beds to basic and advanced medical facilities as well as other cities like Delhi, Bangalore, Mumbai, all basic and advanced medical facilities are available for severely ill patient transport., So that you can get better and comfortable treatment. We do not charge any type of emergency patient for any type of advanced and high-quality medical facilities at the time of transportation.

Migraine Patient Recently Shifted From Kolkata To Delhi By Global Air Ambulance

Do you want to keep your patients safe when they are taken from one city to another for the further treatment and with all the high-tech equipment present inside the ambulance so that patients can be given all the medical facilities according to their need? Our Company recently moved one Migraine patient.

A migraine is a primary headache turmoil characterized by recurring headaches that are restrained to severe. Characteristically, the headaches influence one half of the head, are pulsating in nature, and last from two to 72 hours. Connected symptoms may comprise nausea, vomiting, and sensitivity to light, sound, or smell.

Our Company is mainly standing with the low-cost budget without any hidden or another additional costing which not only makes relaxes to the guests but also satisfies to their budgets. We relocate the patient from one city to another city, our operational teams are well experienced and specialized in this field they easily manage all things and criteria associated with transporting patient within a short span of time. We are one of the top ranking air ambulance service providers as its aim is not to earn money but to give secure service and provide special care to the ICU patients as they need lots of care during translocation from one city to another.

There Are Some Particular Features of our company:-

The tiny burden is for booking time in lieu of Air Ambulance Services
The world-class and notorious medical team in Air Medical Assistance with the lowest rate
Transparent and superiority observing emergency service opted as the briefing goal
Pioneering and Renovated Medical dispatch with successful way anytime
No Extra or concealed Booking Fare instead of authentic and Economical Charges for Rescue urgent service
24/7 Hours availability anytime and anyway on phone after immediate booking, service available soon within a very short time duration

We offer always lower rate and after the updating lowest cost to the needy and it is possible only by our company who always believes in quality, safety, experience, transparency and economic cost in connection with the serious ones anytime, anywhere, and anyhow only after call confirmation. We are 24hours alarmed based quick transfer services where any serious, accidental, sick or chronic patients are being transferred under the supervision of its doctors, paramedics, and nurses from one bed to the desired bed. It endows with full security to the patients and gives them the best service al reliable budget. It has courteous, experienced, and well-trained staff that always available in the Air Ambulance from Kolkata to give immediate treatment to the patients.

This Air Ambulance in Delhi is one of the most time saving, intense assistance and quick service providers by private charter aircraft, commercial airlines evacuation system, medical transfer facility and much more transfer service available. It provides you with the best medical Doctors team and paramedics. We are based on the 24/7 hrs time providing assistance which has great channels of ICU specialist MD doctors’ panels and long time experienced and working for paramedical technicians.

Good,, Bad, and Trans Fats and the Health Risk They Pose

What many don’t realise is that fats are essential for good health. The brain, for instance, is contains fat, but it is the good one and not that which can kill you. As people age they become more susceptible to weight gain and the large stomachs seen in many. The fat around their middle is from bad fats that usually come from things like sugar and trans fats.

Alcohol is the same as sugar in its molecular component. In other words, sugar breaks down into the same structure as alcohol and this is why beer drinkers end up with what is described as a ‘beer gut’. But that is not trans fat but the product of a normal digestive function whereby the ‘sugar’ overloads the liver and turns into fat.

In that case one may end up with a fatty liver and possibly pancreas leading to cancer of the organs. It also leads to diabetes and loss of limbs, eye-sight, and heart disease, among other things.

Then there are the trans-fats and these are normal fats that have undergone transformation due to heat. They take on extra molecules of hydrogen during the process and that makes them virtually indigestible by the liver so that they are laid around the vital organs.

The worst practice comes from super heated and oft heated oils. They are found in commercial ovens where deep fried fish and vegetables are produced. They are the in many of the snack foods people are addicted to while the warning that should accompany them is that they can lead to diseases, as described above, and even death.

Analysis to Next Generation Sequencing Technology

With the development of science, traditional Sanger sequencing has failed to meet new requirements of low cost, high throughput and fast in speed.

Recent years, with the discovery and promotion of second-generation sequencing technology, the gene sequencing speed has increased greatly while achieving a substantial decline in costs, making large-scale application of genome sequencing possible. Now, the cost of personal whole genome sequencing is about 5,000$, and is expected to decreased to less than $ 1,000 in the next few years.

The rapid development of sequencing technology will promote the massive accumulation of DNA sequencing data, accompanied by the accumulation of the corresponding individual diseases, signs and other data at the same time. When we accumulate enough data, how to understand these data will be critical. On the micro level, generations of molecular biologists’ studying the effects of apparent biological traits genes exert on utilizing technologies like gene knockout have made breakthroughs in many crucial aspects. On the macro level, statistics and other data analysis techniques are introduced to study the relationship between gene sequences and biological phenotype. The accumulation of basic scientific research gradually brings breakthroughs in clinical applications.

There are now two types of clinical applications mainly, one aims at disease screening of ordinary people. It infers people’s future risks of getting cancer by measuring the known genes associated with a disease loci. The other aims at the diagnosis cancer and other deadly diseases. It finds in a series of drugs or plans the most effective one for certain patients by testing the loci of certain genes.

Data from BBC research shows that total global gene sequencing market increased from $ 7.941million in 2007 to $ 4.5 billion in 2013, and will reach $ 11.7 billion in the year of 2018 with the CAGR up to 21.2%.

Currently, the market of de novo sequence platform is mainly taken by several major manufacturers, including the Illumina, Ion Torrent / Life Technologies (was the acquisition of Thermo Fisher in 2014), 454 Life Sciences / Roche, etc.

Under such a circumstance, the next generation sequencing technology (second-generation sequencing) appears. As an emerging industry, the next-generation sequencing technology can be applied in clinical testing like antibody discovery, health industry, industrial and agricultural use of gene-oriented study as well as scientific research and development.

A Healthy Dose of Medicine for the Soul

A large segment of the human population takes things way too seriously for their own good. The strange anomaly is that most people laugh at the wrong thing and fail to laugh at the right thing. This serious incongruity has robbed people of a healthy attitude towards life in general.

Those who take life too seriously are in danger of missing the great joys of living in a crazy world like ours. I am not sure about the scientific research but I would guess that for every sad moment it takes one hundred laughs to balance the books. Some people are about ninety-nine laughs short of a real sane moment.

I like the old English proverb that says, “Laugh and the whole world laughs with you, cry and you cry alone.”

From my perspective, if you cannot laugh with someone you will not be able to cry with him or her and have it mean anything.

According to some medical advice, it takes more facial muscles and energy to frown than it does to smile. Of course, the only exercise some people have is frowning and who am I to take that away from them.

I am determined, no matter what, to exercise my right to smile and laugh and enjoy the world around me. I must confess that I get this attitude quite honestly.

My paternal grandfather was a Past Master in the area of practical jokes. No amount of time was too much to spend preparing for one of his famous practical jokes. His favorite holiday was April 1 and began preparing for this holiday right after Christmas.

The fact that his practical jokes at times got him into trouble did not seem to affect him at all.

Once while in the hospital for an extended period he had somebody smuggle in to him a can of snuff. For some reason he liked chewing snuff. It is the most disgusting habit I know of on earth.

He no sooner received his smuggled goods then he began chewing it. If you know anything about chewing snuff, you know it is accompanied by a lot of spitting. As usual, his timing was impeccable. Just as the head nurse passed his door and looked in, he leaned over and spit in to the garbage can he had next to his bed. The nurse, not knowing about the chewing snuff, thought he was spitting blood and immediately went into emergency mode. Immediately my grandfather was rushed into the operating room and the surgeon and medical team were assembled.

My grandfather was very sick at the time. Some did not think he would get out of the hospital.

Just as they got him situated in the operating room he pulled from under his sheet his can of chewing snuff and smiled at them. The only person in the room that thought this was in any way amusing was my grandfather. The doctors were so angry with him that they refused to see him for three days and confiscated his can of chewing snuff.

My aunt and uncle lived right next to my grandfather. My aunt was hyper clean when it came to her house. Dirt in any form was not welcome under her roof. She had a broom that was always within reach because she never knew when a piece of dirt would try to invade her domicile.

That year my grandfather found something new. I am not sure where he found it but he probably spent a lot of time looking for something like this. It was a rubber facsimile of a very nasty looking piece of vomit. To him it was a prized possession.

Most of his practical jokes were executed on April 1. Whenever we saw grandfather coming on this particular day we usually ran for cover.

He went over to visit my aunt and was sitting on the couch in the living room. They chatted for a little while and then my grandfather began to cough a little bit. He said to my aunt, “I haven’t been feeling good lately. I really don’t know what it is.” Then he started to cough a little more seriously, to which, my aunt got up and went to the kitchen to get him a glass of water thinking that might help him.

When she got back, she was shocked to see on her new coffee table a very horrible sight. My grandfather was bent over the coffee table hacking and coughing as though he was in the process of dying. On the coffee table was a very nasty looking piece of vomit.

My aunt went into hysterics. She whirled around and within a moment had grabbed her broom and started towards my grandfather. My grandfather was laughing but not for long.

Suddenly he realized that the flailing broom in my aunt’s hand was aimed at him. She chased him out of the house, down the driveway and for at least three blocks yelling obscenities at him that I dare not repeat in public society.

Environmental Factors for Hair Loss

ENVIRONMENTAL FACTORS OF HAIR LOSS

Hair loss – a common problem which adversely impacts the self-esteem of a number of individuals all over the world. While many people blame the condition entirely on genetics, it is important to know that there are many other factors which contribute to both female and male pattern baldness.

There are numerous individuals know about the way that our encompassing condition can assume a key part in causing male pattern baldness. The beneath specified focuses will tell about the different ecological elements which can prompt male pattern baldness in the two people:

1. Contamination

Debased air contains toxins and cancer-causing agents which can meddle with the protein in charge of hair development bringing about loss of hair. As per researchers, a few poisons can enter the circulatory system, body and skin, and debilitate the hair follicles. It is consequently that spots with a dirtied domain have more number of bare individuals.

2. Hard Water

Hard water is one of the greatest ecological components that prompt male pattern baldness. Late looks into have demonstrated that nations having water with more PPM (parts per million) have more number of uncovered individuals. Higher amounts of magnesium, calcium and silica can cause dryness and harm the hair.

3. Concoction Substances

Barely any compound substances, for example, chlorine found in swimming pools are known to mischief and harm the hair. While there’s nothing concrete over the immediate connection amongst chlorine and sparseness, it is regularly connected to adversely influencing the general prosperity of hair.

4. Warmth and Sun

Drawn out presentation to the sun may bring about perpetual male pattern baldness. A sunburn influencing the scalp can enact Telogen Effluvium, which is a male example hair sparseness condition wherein more than expected follicles enter the resting period of the development cycle. This can exacerbate the male pattern baldness issue.

ADVANTAGES OF HAIR TRANSPLANT

1. There are no complications in hair transplantation:- Hair transplants are very protected. In any case, it’s somewhat of an extend to state that they are without inconvenience. Patients may have redness, swelling and crusting post operatively. When all is said in done, the recuperation in FUE methodology is considerably less demanding than FUT strategies. In any case, there are uncommon difficulties in hair transplant surgery that incorporate dependable nerve torment (more in FUT than FUE systems) and steady scalp redness. Unless a doctor is painstakingly checking the methodology, a patient can even become ill. The hair transplant group tends to bashful far from calling hair transplant systems a ‘surgery’ to make the strategy more patient neighborly – yet don’t imagine it any other way a hair transplant is a surgery.

2. You will regain the hair density of your youth:- A hair transplant is a surgical system which included moving somewhere in the range of 10 to 10,000 hairs into a zone of thinning up top. On the off chance that a region of male pattern baldness is little, it might be conceivable to manufacture some extremely decent thickness in the territory – yet the thickness is for the most part short of what it used to be. For instance, in a patient who is exceptionally uncovered, a thickness of 35-40 follicular units for every square centimeter will regularly be made. This zone likely had a thickness of at least 90 follicular units for every square centimeter at one time years sooner. In this way, it is for the most part the standard for a hair transplant to make comes about that are less thick than the first thickness. A talented specialist can regularly help make 35-40 follicular units resemble the first thickness. Be that as it may, photographs and recordings of patients with incredibly thick and thick hair following their technique may not generally be exact.

DOUBLE-BLINDED MEDICINE: When Doctor and Patient Are Both in the Dark

DOUBLE-BLINDED MEDICINE:

When Doctor and Patient Are

Both in the Dark

I met a dermatologist the other day who made my skin crawl. He was in his thirties, tall, lean, and unsmiling, like many doctors these days. But what stood out most was a fresh-looking, full-color, eye-popping tattoo on his right arm that snaked its way up from his wrist, circumvented his forearm, and slipped beneath his short-sleeved shirt to unknown anatomical areas. I believe he also had a tattoo on his left arm, but I was too gobsmacked at the time to take note.

Now, you might think, as I do, that a tattooed dermatologist is an oxymoron. It doesn’t take much imagination, or research on the Internet, to realize that tattoos are bad for the skin.

The most obvious issue is that tattooing is done by puncturing the skin, causing skin trauma and risk of infection. Interestingly, there is research that connects the injury to the skin made by both tattooing and vaccinations as a cause of numerous skin reactions, including cancer.

The 2014 article, “Tattoo and vaccination sites: Possible nest for opportunistic infections, tumors, and dysimmune reactions”, in the journal Clinical Dermatology, explains that, “Both dermal tattoos and vaccine injections may alter local immune responses, creating an immunocompromised district on or near the site of placement. This can lead to the development of opportunistic infections, benign and malignant tumors, and local dysimmune reactions… A variety of tumors including basal and squamous cell carcinomas, keratoacanthomas, and malignant melanoma also have been reported in association with tattoos… Vaccination sites similarly provide a setting for both benign and malignant tumors.”

The inks used are also a problem, causing allergies and exposure to heavy metals. It is fairly common for individuals to have an allergic reaction to the dyes used in tattoos. Ink is actually filled with many chemicals and unnatural ingredients that can irritate a person’s skin.

There is also a link to skin cancer. When it comes to cancer, black ink can be especially dangerous because it contains a very high level of benzo(a)pyrene. Benzo(a)pyrene is currently listed as a carcinogen by the International Agency for Research on Cancer (IARC). Black ink is the most commonly used color for tattooing.

You might think that this doctor may have gotten his tattoos before becoming a doctor, so he didn’t know any better. But this was a new tattoo. And he was flaunting it, not hiding it.

Tattoos are common these days, and fashionable in certain circles. Doctors want to look cool, like everyone else. They grew up like everyone else, exposed to, and brainwashed by, the same cultural messages. They just choose to go into medicine.

I also met a cardiologist who smoked cigarettes. He was also grossly overweight, and ate a big, juicy hamburger with fries for lunch. Of course, being obese, smoking and eating fried foods can increase heart disease.

An obese, smoking cardiologist eating fast food makes as much sense as a tattooed dermatologist.

Maybe these doctors are attracted to their specialties because they know they will need treatment from that specialty due to their lifestyles? It’s like when mentally-disturbed, neurotic people become psychologists or psychiatrists.

How about female doctors who constrict their breasts with tight bras for long hours daily? There are many female breast health experts, including breast surgeons, who wear breast-harming bras. Their medical training never mentioned tight clothing as a cause of circulatory impairment and lymph stasis. These doctors willingly immobilize and alter their breast shape, hide their nipples, and basically re-design their breast appearance for cultural reasons, and do this despite the documented harms caused by bras, including causing breast pain, cysts, and cancer. Wearing bras is just something every woman is culturally expected to do, even doctors.

Is this hypocrisy? Should we expect doctors to be paragons of health and healthy lifestyles?

More basically, when we seek help, does it matter whether the helper is in the same mess we are in? In other words, can you trust a lifeline from someone in the same boat as you?

We seek help in many places.

Would you go to a priest who was a known pedophile?

Would you use a mechanic whose car is broken down?

Would you go to a hairdresser who is having a “bad hair day”?

Would you use a plastic surgeon who has a big nose, cock-eyed chin, and facial scars?

How about eating in a restaurant where the cook is out because of food poisoning?

You could also go into a health food store and buy chips, coffee, candy, wine, beer, and lots of other unhealthy stuff.

Then there are the drug addiction recovery programs that offer coffee to everyone, one of the most addictive substances we consume.

Clearly, there’s a problem here. We live in a culture where there are lots of products and activities that can harm us. In fact, the biggest cause of disease and death is the culture and all the bad things it teaches us to think, do and feel. We absorb these cultural messages from the uterus onward, as our nature becomes modified by our culture.

This applies to everyone. It includes doctors, too. Just because someone studied medicine, it does not mean that they personally eliminated all harmful cultural practices in their lives. The same cultural causes of disease that fill their waiting rooms also fill their personal lives. In fact, the medical culture is even worse on doctors.

For some reason that is not clear, the medical system exploits doctors with long work hours and sleepless day and night shifts. Doctors are rushed and pressured, grabbing unhealthy snacks on the go. They become tempted to abuse drugs to keep going, but may settle for drinking 10-20 cups of strong coffee, instead. They also become tempted to use drugs to relax, but may settle for a few alcoholic drinks. They have little recreation time, or time with their families. And depending on their specialty, they are exposed daily to infectious diseases, death, radiation, the soul-robbing sights and smells of hospitals, and the depression of treating endless lines of sick people, often using treatments that do no good, and for conditions that have no known cause.

Clearly, being a doctor can make you sick, mentally and physically. No wonder why there are so many doctor suicides. Just practicing medicine is slow suicide.

This also means that doctors are not the ones to tell patients to clean up their lifestyles. The doctor’s lifestyle is at least as bad, and actually worse. They participate in the same unhealthy culture as everyone else, addicted to many of the same things, and suffering from the same psychological and physical issues. But they are the ones who are meant to treat those problems.